OMEICOS Therapeutics GmbH - Posters & Publications

Posters & Publications

OMEGA-3 anti-arrhythmic

Dietary omega-3 fatty acids modulate the eicosanoid profile in man primarily via the CYP-epoxygenase pathway.
Fischer R, Konkel A, Mehling H, Blossey K, Gapelyuk A, Wessel N, von Schacky C, Dechend R, Muller DN, Rothe M, Luft FC, Weylandt K, Schunck WH.; J Lipid Res. 2014 Mar 16;55(6):1150-1164.
ico link  http://www.ncbi.nlm.nih.gov/pubmed/24634501
 
Arachidonic acid-metabolizing cytochrome P450 enzymes are targets of {omega}-3 fatty acids.
Arnold C, Markovic M, Blossey K, Wallukat G, Fischer R, Dechend R, Konkel A, von Schacky C, Luft FC, Muller DN, Rothe M, Schunck WH.; J Biol Chem. 2010 Oct 22;285(43):32720-33. doi: 10.1074/jbc.M110.118406.
ico link  http://www.ncbi.nlm.nih.gov/pubmed/20732876
 
Dietary n-3 polyunsaturated fatty acids and direct renin inhibition improve electrical remodeling in a model of high human renin hypertension.
Fischer R, Dechend R, Qadri F, Markovic M, Feldt S, Herse F, Park JK, Gapelyuk A, Schwarz I, Zacharzowsky UB, Plehm R, Safak E, Heuser A, Schirdewan A, Luft FC, Schunck WH, Muller DN.; Hypertension. 2008 Feb;51(2):540-6.
ico link  http://www.ncbi.nlm.nih.gov/pubmed/18158339
 
CYP2J2 overexpression protects against arrhythmia susceptibility in cardiac hypertrophy.
Westphal C, Spallek B, Konkel A, Marko L, Qadri F, DeGraff LM, Schubert C, Bradbury JA, Regitz-Zagrosek V, Falck JR, Zeldin DC, Müller DN, Schunck WH, Fischer R.; PLoS One. 2013 Aug 30;8(8):e73490. doi: 10.1371/journal.pone.0073490.
ico link  http://www.ncbi.nlm.nih.gov/pubmed/24023684
 
Cytochrome p450 enzymes in the bioactivation of polyunsaturated Fatty acids and their role in cardiovascular disease.
Westphal C, Konkel A, Schunck WH.; Adv Exp Med Biol. 2015;851:151-87. doi: 10.1007/978-3-319-16009-2_6. Review.
ico link  http://www.ncbi.nlm.nih.gov/pubmed/26002735
 
CYP-eicosanoids--a new link between omega-3 fatty acids and cardiac disease?
Westphal C, Konkel A, Schunck WH.; Prostaglandins Other Lipid Mediat. 2011 Nov;96(1-4):99-108. doi:10.1016/j.prostaglandins.2011.09.001, Review.
ico link  http://www.ncbi.nlm.nih.gov/pubmed/21945326
 
Role of cytochrome P450 enzymes in the bioactivation of polyunsaturated fatty acids.
Konkel A, Schunck WH.; Biochim Biophys Acta. 2011 Jan;1814(1):210-22. doi: 10.1016/j.bbapap.2010.09.009.
ico link  http://www.ncbi.nlm.nih.gov/pubmed/20869469
 

AMD

Cytochrome P450-generated metabolites derived from ω-3 fatty acids attenuate neovascularization.
Yanai R, Mulki L, Hasegawa E, Takeuchi K, Sweigard H, Suzuki J, Gaissert P, Vavvas DG, Sonoda KH, Rothe M, Schunck WH, Miller JW, Connor KM.; Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9603-8. doi: 10.1073/pnas.1401191111. Epub 2014 Jun 16.
ico link  http://www.ncbi.nlm.nih.gov/pubmed/24979774
 

Vasodilatory Effect

The vasodilator 17,18-epoxyeicosatetraenoic acid targets the pore-forming BK alpha channel subunit in rodents.
Hercule HC, Salanova B, Essin K, Honeck H, Falck JR, Sausbier M, Ruth P, Schunck WH, Luft FC, Gollasch M.; Exp Physiol. 2007 Nov;92(6):1067-76.
ico link  http://www.ncbi.nlm.nih.gov/pubmed/17675416

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