– Addition of 2nd independent board member positions OMEICOS well for future value creation –

OMEICOS Therapeutics, a biopharmaceutical company developing first-in-class small molecule therapeutics for the prevention and treatment of cardiovascular and ophthalmic diseases, today announced the appointment of Christian Schetter, Ph.D., as an independent Board Member.

Christian has over 20 years’ industry experience across the life sciences sector, and most recently joined venture capital firm Arix Bioscience plc as an Entrepreneur in Residence. Before that he was instrumental in building German immuno-oncology company Rigontec GmbH as their CEO and managed the integration process after Rigontec was acquired by MSD in 2017. His appointment adds a second independent board member to the OMEICOS board complementing the position of Dr. Bernd Kirschbaum as Chairman of the Supervisory Board.

Dr. Bernd Kirschbaum, Chairman of the Supervisory Board commented: “Bringing Christian on board, an experience leader who has gone through the process of building up biopharmaceutical start-ups, delivering on the important value inflection points in R&D and taking the next steps in corporate development, adds valuable expertise to the OMEICOS board. With two independent board members, in addition to the experienced board representation from our investors already in place, OMEICOS is well equipped for the next corporate development steps.”

“We welcome Christian to our Supervisory Board and are looking forward to working with him as OMEICOS enters a very exciting stage in its development. Christian’s appointment adds a second independent board member to our team, following Bernd Kirschbaum’s addition to the board in 2015 whose years of R&D leadership at pharmaceutical companies have been and will continue to be essential as we advance our lead compound in Atrial Fibrillation towards proof-of-concept in patients and continue expanding our development pipeline with our subsidiary OMEICOS Ophthalmics in Boston. Taken together, Bernd and Christian bring two unique sets of experience and expertise to OMEICOS,” added Robert Fischer, MD, CEO/CSO of OMEICOS Therapeutics.

Prior to his role at Rigontec GmbH, Christian was President and CEO of Neovii Biotech (previously Fresenius Biotech). During his tenure, one antibody product was brought to market and the indication for another product expanded. Christian was also instrumental in selling Fresenius Biotech to the Neopharm Group, Israel, to form Neovii Biotech and positioning it as a successful standalone business. He was SVP of European Operations at Coley Pharmaceutical Group and Managing Director of Coley GmbH. Christian was part of the leadership team which built Coley Pharmaceuticals from inception through multiple financing rounds, a NASDAQ IPO and, following several significant pharma deals, to a trade sale to Pfizer in 2007. Before entering the life science industry, Christian was successfully performing academic research at the Max Planck Institute in Martinsried, Germany. He received his undergraduate degree and PhD from the University of Cologne and did postdoctoral research in oncology and virology at the Scripps Research Institute in La Jolla, California.

ABOUT OMEICOS

OMEICOS Therapeutics is a spin-off company from the Max Delbrueck Center for Molecular Medicine (MDC) in Berlin. The company has discovered a series of metabolically robust synthetic analogues of omega-3 fatty acid-derived epoxyeicosanoids that have the potential to treat inflammatory, cardiovascular and other diseases. Epoxyeicosanoids, as a newly described class of bioactive lipid mediators, activate cell type-specific endogenous pathways that promote organ and tissue protection. OMEICOS’ small molecules are orally available and show improved biological activity and pharmacokinetic properties compared to their natural counterparts. OMEICOS’ technology is based on ground-breaking scientific results in the field of omega-3 fatty acid metabolism and physiology obtained by the companies’ founders, Dr. Wolf-Hagen Schunck, Prof. John. R. Falck, Prof. Dominik Mueller and Dr. Robert Fischer. The companies’ research activities are supported by a grant from the German Ministry of Education and Research (BMBF). www.omeicos.com

CONTACTS

OMEICOS Therapeutics GmbH
Dr. Robert Fischer, CEO, CSO
Phone: +49 (0) 30 9489 4810
E-Mail: r.fischer@omeicos.com
www.omeicos.com

MEDIA REQUESTS

MacDougall Biomedical Communications
Mario Brkulj or Amanda Whelan
Main: +49 89 2424 3494 or +1 781-235-3060
E-Mail: omeicos@macbiocom.com

Appointment marks further progress in ramping-up US-based subsidiary as validation of OMEICOS’ lead compound also progresses through clinical trials in atrial fibrillation

OMEICOS Therapeutics, a Berlin-based biopharmaceutical company developing first-in-class small molecule therapeutics for the prevention and treatment of cardiovascular and ophthalmic diseases, today announced the appointment of Alexander Gebauer, MD, Ph.D., to the Company’s Management Board.

Dr. Gebauer will lead the clinical development efforts of OMEICOS Therapeutics GmbH. He has also been appointed to Chief Executive Officer and Chairman of the Board of the recently founded US-based subsidiary, OMEICOS Ophthalmics. Dr. Gebauer joins the OMEICOS leadership team with over 25 years of R&D experience within the biotechnology and pharmaceutical industry.

“Alexander’s impressive track record of accomplishments, most notably his success with leading regulatory organizations resulting in numerous approvals, provides OMEICOS with additional experienced leadership to mature our diverse pipeline,” said Robert Fischer, MD, CEO of OMEICOS Therapeutics. “As the development of our lead compound progresses through the clinic and our US subsidiary OMEICOS Ophthalmics accelerates its pace, adding breadth to the management team of OMEICOS is a crucial step in building the organization’s global footprint.”

“OMEICOS is entering a very exciting and promising phase of its corporate development. With Robert as CEO and today’s addition of Alexander as Managing Director we feel the OMEICOS team is very well positioned to progress its growing pipeline steadily towards its next value inflection point,” commented Dr. Bernd Kirschbaum, Chairman of the Board of OMEICOS.

In his role as Managing Director, Dr. Gebauer will oversee the clinical development of OMEICOS’ lead compound OMT-28 for rhythm control in patients with atrial fibrillation. Together with the team, he will steer the planning and clinical trial design for the upcoming Phase II trial in atrial fibrillation for which OMEICOS is currently raising additional capital. As Chief Executive Officer of OMEICOS Ophthalmics Inc., Dr. Gebauer is responsible for the advancement of OMEICOS’ drug discovery prospects in ophthalmology.

This includes establishing further preclinical proof of concept with an external network of renowned experts in the field.

Dr. Gebauer commented, “OMEICOS has tremendous potential to make a fundamental change in the treatment of cardiovascular and ophthalmic diseases. I look forward to building on the company’s successes that have been achieved to date, capitalizing on expertise in the cardiology and ophthalmology fields which I gained in my previous roles.”

Prior to joining OMEICOS Therapeutics, Dr. Gebauer served in a multitude of R&D roles, including Managing Director, President of Global R&D, Chief Scientific Officer and other executive committee positions at several international pharmaceutical companies such as Sun Pharmaceuticals, Ranbaxy Laboratories Ltd., Merz Pharmaceuticals Hoechst AG, Aventis and Sanofi. Dr. Gebauer studied medicine at Johann Gutenberg University, Mainz/Germany, where he completed his thesis in pharmacology.

About OMEICOS OMEICOS Therapeutics is a spin-off company from the Max Delbrueck Center for Molecular Medicine (MDC) in Berlin. The company has discovered a series of metabolically robust synthetic analogues of omega-3 fatty acid-derived epoxyeicosanoids that have the potential to treat inflammatory, cardiovascular and other diseases. Epoxyeicosanoids, as a newly described class of bioactive lipid mediators, activate cell type-specific endogenous pathways that promote organ and tissue protection.

OMEICOS’ small molecules are orally available and show improved biological activity and pharmacokinetic properties compared to their natural counterparts. OMEICOS’ technology is based on ground-breaking scientific results in the field of omega-3 fatty acid metabolism and physiology obtained by the companies’ founders, Dr. Wolf-Hagen Schunck, Prof. John. R. Falck, Prof. Dominik Mueller and Dr. Robert Fischer. The companies’ research activities are supported by a grant from the German Ministry of Education and Research (BMBF). www.omeicos.com

Contacts

OMEICOS Therapeutics GmbH
Dr. Robert Fischer, CEO, CSO
Phone: +49 (0) 30 9489 4810
E-Mail: r.fischer@omeicos.com
www.omeicos.com

Media requests

MacDougall Biomedical Communications
Mario Brkulj or Kara Mazey
Main: +49 89 2424 3494 or +1 781-235-3060
E-Mail: omeicos@macbiocom.com

Leading Experts in Atrial Fibrillation to Complement the Company’s Key Focus Area

OMEICOS Therapeutics, a Berlin-based biopharmaceutical company developing first-in-class small molecule therapeutics for the prevention and treatment of cardiovascular and ophthalmic diseases, today announced the appointment of leading experts in the field of cardiac arrhythmias to the company’s Clinical Advisory Board (CAB). The multinational group of specialists will serve as a strategic resource to OMEICOS as it continues to advance its lead compound, OMT-28, currently in a Phase I clinical trial. The CAB will provide counsel to the company as OMEICOS starts to design a Phase II program for maintenance of sinus rhythm in patients with atrial fibrillation.

The inaugural CAB meeting was held adjacent to the American Hearts Associations’ Scientific Sessions 2017 in Anaheim, CA. The initial members of OMEICOS’ Clinical Advisory Board include:

Leonardo Caló, MD, Chief of the Department of Cardiology at Policlinic Casillino, Rome and Professor of Medicine at University Cattolica, Rome (Italy)

John Camm, MD, FRCP, Professor of Clinical Cardiology at St. George’s Hospital, University of London and at Imperial College, London (United Kingdom)

Dobromir Dobrev, MD, Professor and Director of Institute of Institute of Pharmacology, University of Duisberg-Essen (Germany)

Andreas Goette, MD, FEHRA, Professor and Head of Department of Cardiology and Intensive Care Medicine at St. Vincenz Hospital, Paderborn (Germany)

Gerald Naccarelli, MD, FACC, FAHA, FHRS, Bernard Trabin Chair in Cardiology, Professor of Medicine and Chief of the Division of Cardiology at Pennsylvania State University College of Medicine/Milton S Hershey Medical Center, Pennsylvania (USA)

“We are extremely pleased to have attracted a group of world-renowned leaders to one of our key focus areas, atrial fibrillation” said Robert Fischer, MD, CEO of OMEICOS. “The addition of these seasoned experts to OMEICOS’ Clinical Advisory Board is a testament to the potential of our program and we look forward to their invaluable scientific and clinical development expertise as we shape our strategy to develop an effective therapeutic to achieve long term rhythm control in patients with AF.”

Dr. Leonardo Caló is focused on studying cardiac arrhythmias, electrophysiology and ablation and is an expert in the functional role played by omega-3 fatty acids in the prevention of arrhythmias in different settings. He is a Fellow of the European Society of Cardiology and has participated in several international clinical trials. He is associated Editor of Journal of Cardiovascular Interventional Electrophysiology and European Journal of Preventive Cardiology, has authored or co-authored numerous papers and more than 20 book chapters. Prof. Caló has participated in several international clinical trials.

Dr. John Camm is focused on cardiac arrhythmias, atrial fibrillation, stroke prevention, clinical cardiac electrophysiology, heart failure and cardiomyopathy patients. He is President of the European Heart Rhythm Association and Founder of the Atrial Fibrillation Association and in addition, a Fellow of the Royal College of Physicians (London, Edinburgh and Glasgow), the American College of Cardiology, the American Heart Association and the European Society of Cardiology (ESC). Prof. Camm has written or edited more than 40 books and has authored or co-authored almost 1300 peer reviewed papers and over 500 book chapters in the field of cardiology and has been involved in the production of numerous guidelines, including the ESC guidelines for the management of atrial fibrillation. In 2010 and 2012, he was the recipient of the ESC Gold Medal and the British Cardiovascular Society’s Mackenzie Medal.

Dr. Dobromir Dobrev is an internationally recognized expert in understanding the cellular and molecular mechanisms underlying development, progression and maintenance of cardiac arrhythmias, particularly atrial fibrillation. He has authored over 200 peer reviewed articles and is on the editorial board of numerous cardiovascular journals. He is currently Chairman of ESC Working Group on Cardiac Cellular Electrophysiology and co-authored the 2016 ESC guidelines for the management of atrial fibrillation.

Dr. Andreas Goette is a specialist in interventional cardiology as well as clinical and experimental electrophysiology. The main focus of his research is on molecular mechanisms and molecular biology of atrial fibrillation. Since 2015 he is one of the Chairman of the German Atrial Fibrillation NETwork (AFNET). He was the Chair of the Scientific Program Committee of the European Heart Rhythm Association (EHRA), co-authored various international guidelines in atrial fibrillation treatment and published more than 150 peer reviewed papers.

Dr. Gerald Naccarelli is a cardiologist and arrhythmia expert who has been in clinical practice for 36 years. He is past-president of the Heart Rhythm Society (HRS) and served on the Board of Trustees of the American College of Cardiology and HRS. He is a recipient of the American Heart Association’s Paul Dudley White Award. Prof. Naccarelli has published over 600 peer reviewed papers, book chapters and reviews in addition to authoring four books related to cardiac arrhythmia. He is currently on the steering committee of multiple clinical trials and has vast experience in the development and approval of multiple anti-arrhythmic agents in the USA.

About Atrial Fibrillation Atrial fibrillation (AF) is the most common cardiac arrhythmia in humans. More than 30 million patients are affected worldwide and this number is increasing by 2% per year due to the aging population. AF is characterized by an irregular heart rhythm originating from the heart’s upper chambers, resulting in inefficient blood pumping. AF leads to a significant reduction in quality of life, increases the risk of stroke, raises the risk of heart failure and doubles the risk of death. Marketed anti-arrhythmic drugs have limited efficacy and often severe adverse effects, which together with the huge number of affected patients accounts for a high unmet medical need for a safe and efficacious medical treatment of AF.

About OMEICOS

OMEICOS Therapeutics is a spin-off company from the Max Delbrueck Center for Molecular Medicine (MDC) in Berlin. The company has discovered a series of metabolically robust synthetic analogues of omega-3 fatty acid-derived epoxyeicosanoids that have the potential to treat inflammatory, cardiovascular and other diseases. Epoxyeicosanoids, as a newly described class of bioactive lipid mediators, activate cell type-specific endogenous pathways that promote organ and tissue protection. OMEICOS’ small molecules are orally available and show improved biological activity and pharmacokinetic properties compared to their natural counterparts. OMEICOS’ technology is based on ground-breaking scientific results in the field of omega-3 fatty acid metabolism and physiology obtained by the companies’ founders, Dr. Wolf-Hagen Schunck, Prof. John. R. Falck, Prof. Dominik Müller and Dr. Robert Fischer. The companies’ research activities are supported by a grant from the German Ministry of Education and Research (BMBF).  www.omeicos.com

Contact

OMEICOS Therapeutics GmbH
Dr. Robert Fischer, Chief Scientific Officer and Managing Director
Phone: +49 (0) 30 9489 4810
E-Mail: r.fischer@omeicos.com
www.omeicos.com

Media requests

MacDougall Biomedical Communications
Mario Brkulj or Dr. Jacob Verghese
Main: +49 89 2424 3494 or +49 175 501 0575
E-Mail: mbrkulj@macbiocom.com