Development of robust 17,18‑EEQ analogs as potential clinical antiarrhythmic agents
Adebesin et al. J Med Chem 2019
VISIT

Development of metabolically robust 17,18-EEQ analogs
Falck et al. J Med Chem 2011
VISIT

Cardioprotective effects of CYP-derived epoxymetabolites of docosahexaenoic acid involve limiting NLRP3 inflammasome activation
Darwesh et al. Can J Physiol Pahrmacol 2019
VISIT

Novel Roles of Epoxyeicosanoids in Regulating Cardiac Mitochondria
El-Sikhry et al. PLoS One 2016
VISIT

17,18-EEQ becomes the major upregulated EPA-metabolite when omega-3 fatty acid supplementation is given to man
Fischer et al. J Lipid Res 2014
VISIT

In transgenic mice overexpression of human epoxygenase CYP2J2 confers protection against ventricular tachycardia and atrial fibrillation
Westphal et al. PLoS One 2013
VISIT

CYP-eicosanoids – a new link between omega-3 fatty acids and cardiac disease?
Westphal et al. Prostaglandins Other Lipid Mediat. 2011
VISIT

Role of cytochrome P450 enzymes in the bioactivation of polyunsaturated fatty acids
Konkel and Schunck, Biochim Biophys Acta. 2011
VISIT

CYP enzymes efficiently convert EPA and DHA to novel bioactive lipid mediators that probably contribute to the cardiovascular beneficial effects of dietary omega-3 fatty acids. CYP2J2, the major CYP epoxygenase in the human heart prefers EPA as substrate and converts it to 17,18-EEQ
C Arnold et al. JBC 2010
VISIT

Relevance of soluble Epoxide Hydrolase (enzyme which is quickly de-activating 17,18-EEQ) in heart failure development – supporting evidence for relevance of CYP pathway as a therapeutic target in heart diseases
Monti et al. Nature Med 2008
VISIT

Cardioprotective Properties of OMT-28
Kranrod et al. JBC 2024
VISIT

Pulmonary Hypertension: Omega-3 epoxyeicosanoids reduce development of PH
Moriyama et al. Nature Comm 2022
VISIT

Endotoxemia: Amerlioration of endotoxemia by a synthetic analog of omega-3 epoxyeicosanoids
Shikuma et al. Front Immunol 2022
VISIT

Heart Failure: Mitochondrial Dysfunction and Inflammaging in Heart Failure: Novel Roles of CYP-Derived Epoxylipids
Keshavarz-Bahaghighat et al. Cells 2020
VISIT

Atrial Fibrillation: Assessment of OMT-28, a synthetic analog of omega-3 epoxyeicosanoids, in patients with persistent atrial fibrillation: Rationale and design of the PROMISE-AF phase II study
Berlin et al. Int J Cardiol Heart Vasc 2020
VISIT

Review: Therapeutic potential of omega-3 fatty acid-derived epoxyeicosanoids in cardiovascular and inflammatory diseases
Schunck et al. Pharmacol Ther 2018
VISIT

Chorideal Neovascularization: 17,18-EEQ and stable synthetic analog C21 reduce chorideal neovascularization via a immunomodulatory mechanism of action
Hasegawa et al. PNAS 2017
VISIT

Chorideal Neovascularization: 17,18-EEQ as active EPA metabolite, mediating reduction of chorideal neovascularization
Yanai et al. PNAS 2013
VISIT